Construction of the State Hospital at Northampton, the third state institution for the insane in the state of Massachusetts began on March 15, 1856 on top of Hospital Hill. The asylum received its first patients on August 16, 1858. Within six weeks, the population would reach 220, most of whom were transfers from other institutions long overwhelmed. After 130 years, Old Main was abandoned in 1986. Operations at Memorial Complex continued until 1993, when the last 12 patients were reassigned, and Northampton State Hospital was officially closed.

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